Tenecteplase versus standard medical treatment for basilar artery occlusion within 24 h (TRACE-5)
a multicentre, prospective, randomised, open-label, blinded-endpoint, superiority, phase 3 trial
The TRACE-5 trial demonstrated that intravenous tenecteplase within 24 hours improved functional outcomes in Chinese patients with ischemic stroke due to basilar artery occlusion. The results support thrombolysis as an effective treatment for this devastating posterior circulation stroke subtype.
Summary
In this trial involving Chinese patients with ischaemic stroke due to basilar artery occlusion, tenecteplase within 24 h after stroke onset improved functional outcome compared with standard medical treatment. The incidence of symptomatic intracranial haemorrhage and death was similar.
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