N-of-1 Trial of a Statin, Placebo, or No Treatment to Assess Side Effects.
The StatinWISE N-of-1 trial demonstrated that muscle symptoms attributed to statins were largely not reproducible under blinded conditions, with similar symptom scores during statin and placebo periods. This provided rigorous evidence that most statin-associated side effects are attributable to the nocebo effect rather than the drug itself.
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