In a prospective cohort study of 18,741 patients with type 2 diabetes on lipid-lowering therapy, elevated remnant cholesterol and hsCRP levels were each independently associated with a higher risk of…
New England Journal of Medicine; AHA 2026 late-breaking abstractCholesterolPrimary care
the ANGPTL4 antibody MAR001 lowers triglycerides up to 45.5 percent more than placebo without worsening glucose, and a single CRISPR infusion against ANGPTL3 removes 63 percent of triglycerides in ten patients with severe hypertriglyceridaemia
Two early-phase lipid trials from LBS.05 at AHA 2026 (Monday 9 November). TYDAL-TIMI 78 Part A, presented by Michelle O'Donoghue (TIMI Study Group) and published simultaneously in NEJM: 235 adults…
Circulation: Population Health and OutcomesCholesterolLifestyle
pelacarsen lowers lipoprotein(a) by 86 percent in 423 Black and Hispanic Americans with cardiovascular disease, the same reduction that prevented no events in Lp(a)HORIZON
Presented in FS.12 at AHA 2026 (Monday 9 November) and published simultaneously in Circulation: Population Health and Outcomes. Lp(a)FRONTIERS EXPANSION, a US phase 3b randomised, double-blind…
New England Journal of MedicineCholesterolLifestyle
pelacarsen lowers lipoprotein(a) by 78 percent but prevents no events, hazard ratio 1.02 in 8,322 patients over 4.7 years
Presented in LBS.01 at AHA 2026 (Saturday 7 November) and published simultaneously in NEJM, with the extended analyses in NEJM Evidence. Lp(a)HORIZON randomised 8,350 patients (8,322 analysed; mean…
European journal of preventive cardiologyCholesterolDiabetes
Pooled Analysis of BROADWAY/BROOKLYN and an Updated Meta-analysis of CETP Inhibitor Trials.
A pooled analysis of phase 3 trials (BROADWAY/BROOKLYN) and an updated meta-analysis evaluated the impact of the CETP inhibitor obicetrapib on glycaemia and new-onset diabetes in 1,700 participants…
Annals of internal medicineCholesterolPrimary care
The 2025 VA/DoD clinical practice guideline on lipid management introduces updated cardiovascular risk assessment tools, including the PREVENT calculator, one-time lipoprotein(a) testing, and…
Modern Lipid Management for ASCVD Prevention in Primary Care.
This narrative review outlines the evolving landscape of lipid management for atherosclerotic cardiovascular disease (ASCVD) prevention in primary care and cardiology. Beyond traditional risk scores…
New England Journal of MedicineCholesterolPrimary care
atorvastatin 40 mg in healthy adults over 70 prevents 30 percent of cardiovascular events but does not extend disability-free survival
The trial the primary-care question has waited for: 9,971 healthy Australians aged 70 and over (mean 74.7, 52 percent women) randomised to atorvastatin 40 mg or placebo, median follow-up 5.9 years…
evolocumab in the cath lab gets 82 percent of infarct patients to LDL target within a year, without a demonstrable clinical difference
International open-label phase 4 trial: 2,161 patients with high-risk acute MI undergoing PCI, evolocumab 140 mg every two weeks for one year with the first dose given before PCI, versus standard…
STAREE randomised almost 10,000 healthy Australians aged 70 and over to atorvastatin or placebo, with disability-free survival as its primary endpoint. Presented in Hot Line 2 at ESC Congress 2026…
Atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of morbidity and mortality in diabetes, partly driven by dyslipidaemia. Although LDL cholesterol (LDL-C) is the primary…
European journal of preventive cardiologyCholesterolObesity
The combined value of lipoprotein(a) [Lp(a)] and high-sensitivity CRP (hsCRP) in primary prevention among people without standard modifiable risk factors (SMuRF-less: no smoking, obesity…