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Cholesterol

12 lectures · 135 items

Video lectures

Science updates · Society updates

FIMMG National Congress Italy: strengthening dyslipidaemia management in primary careThe Pulse of Primary Care - EPCCS Summit 2026Talking to Patients About Statins: Why Most Reported Symptoms Aren't CausalGPcardio and ACC’s NCD Academy Join Forces to Strengthen Primary Care in Cardiovascular Disease PreventionSex Differences and Trends in Cardiovascular Risk Management: Insights from a Long-Term Primary Care StudyPrimary Prevention of Atherosclerotic Cardiovascular Disease (ASCVD) in Primary care: A Systematic Review of GuidelinesStudy on Cardiovascular Risk Factors and Primary Care Utilization in SpainGlobal Insights from the INTERASPIRE Study: Mapping Lipoprotein(a) Prevalence in Coronary Heart Disease Across Six WHO RegionsWeb app effective in determining access to statins without a prescriptionSlides | Take home messages of EPCCS Guidance on 'Managing elevated lipids in primary care'Lečenje povišenih lipida u primarnoj zdravstvenoj zaštiti (PZZ)Managementul dislipidemiei în asistența medicală primarăManaging elevated lipids in primary careManaging elevated lipids and statins – the good, the bad and the ugly?Slides | Lipid-lowering: the evidence, the guidelines, the clinical realityLipid Management: What do the guidelines say and what are the implications for primary care?

Literature

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New England Journal of Medicine; AHA 2026 late-breaking abstractCholesterolPrimary care

TYDAL-TIMI 78 and CTX310

the ANGPTL4 antibody MAR001 lowers triglycerides up to 45.5 percent more than placebo without worsening glucose, and a single CRISPR infusion against ANGPTL3 removes 63 percent of triglycerides in ten patients with severe hypertriglyceridaemia

Two early-phase lipid trials from LBS.05 at AHA 2026 (Monday 9 November). TYDAL-TIMI 78 Part A, presented by Michelle O'Donoghue (TIMI Study Group) and published simultaneously in NEJM: 235 adults…

Circulation: Population Health and OutcomesCholesterolLifestyle

Lp(a)FRONTIERS EXPANSION

pelacarsen lowers lipoprotein(a) by 86 percent in 423 Black and Hispanic Americans with cardiovascular disease, the same reduction that prevented no events in Lp(a)HORIZON

Presented in FS.12 at AHA 2026 (Monday 9 November) and published simultaneously in Circulation: Population Health and Outcomes. Lp(a)FRONTIERS EXPANSION, a US phase 3b randomised, double-blind…

New England Journal of MedicineCholesterolLifestyle

Lp(a)HORIZON

pelacarsen lowers lipoprotein(a) by 78 percent but prevents no events, hazard ratio 1.02 in 8,322 patients over 4.7 years

Presented in LBS.01 at AHA 2026 (Saturday 7 November) and published simultaneously in NEJM, with the extended analyses in NEJM Evidence. Lp(a)HORIZON randomised 8,350 patients (8,322 analysed; mean…

European journal of preventive cardiologyCholesterolDiabetes

Effect of Obicetrapib on Glycaemia and New-Onset Diabetes

Pooled Analysis of BROADWAY/BROOKLYN and an Updated Meta-analysis of CETP Inhibitor Trials.

A pooled analysis of phase 3 trials (BROADWAY/BROOKLYN) and an updated meta-analysis evaluated the impact of the CETP inhibitor obicetrapib on glycaemia and new-onset diabetes in 1,700 participants…

Cardiology and therapyCholesterolPrimary care

Beyond LDL-C

Modern Lipid Management for ASCVD Prevention in Primary Care.

This narrative review outlines the evolving landscape of lipid management for atherosclerotic cardiovascular disease (ASCVD) prevention in primary care and cardiology. Beyond traditional risk scores…

New England Journal of MedicineCholesterolPrimary care

STAREE

atorvastatin 40 mg in healthy adults over 70 prevents 30 percent of cardiovascular events but does not extend disability-free survival

The trial the primary-care question has waited for: 9,971 healthy Australians aged 70 and over (mean 74.7, 52 percent women) randomised to atorvastatin 40 mg or placebo, median follow-up 5.9 years…

JAMACholesterolPrimary care

AMUNDSEN

evolocumab in the cath lab gets 82 percent of infarct patients to LDL target within a year, without a demonstrable clinical difference

International open-label phase 4 trial: 2,161 patients with high-risk acute MI undergoing PCI, evolocumab 140 mg every two weeks for one year with the first dose given before PCI, versus standard…

HartVaat congresredactieCholesterolPrimary care

Statins beyond seventy

what STAREE will and will not answer

STAREE randomised almost 10,000 healthy Australians aged 70 and over to atorvastatin or placebo, with disability-free survival as its primary endpoint. Presented in Hot Line 2 at ESC Congress 2026…

Cardiovascular diabetologyCholesterolDiabetes

Lipid management in type 2 diabetes and non-HDL-cholesterol

target all atherogenic lipoproteins.

Atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of morbidity and mortality in diabetes, partly driven by dyslipidaemia. Although LDL cholesterol (LDL-C) is the primary…

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