the once-daily GLP-1 pill orforglipron lowers the apnoea-hypopnoea index in moderate to severe sleep apnoea with obesity by 12 to 13 events per hour more than placebo, with 10 percent weight loss and 7 mmHg lower blood pressure
Presented in LBS.05 at AHA 2026 (Monday 9 November) by Vaishnavi Kundel (Mount Sinai) and published simultaneously in JAMA (first author Atul Malhotra). ATTAIN-OSA comprises two 52-week, phase 3…
New England Journal of MedicineHypertensionPrimary care
a systolic target below 120 mmHg after ischaemic stroke or TIA gives 21 percent fewer cardiovascular events than below 140, at the price of more renal function decline
Presented in LBS.02 at AHA 2026 (Saturday 7 November, Gisele Sampaio Silva, Federal University of Sao Paulo) and published simultaneously in NEJM. OPTIMAL-Stroke randomised 4,368 adults (mean age…
New England Journal of MedicineHypertensionPrimary care
a systolic target below 120 mmHg in type 2 diabetes does not significantly lower cardiovascular events (6.0 versus 6.7 percent) and gives more renal function decline
Presented in LBS.03 at AHA 2026 (Saturday 7 November, Karla Santo, Hospital Israelita Albert Einstein, Sao Paulo) and published simultaneously in NEJM. OPTIMAL-DIABETES randomised 9,476 adults aged…
A systematic review and Bayesian network meta-analysis.
A Bayesian network meta-analysis of 284 RCTs (18,750 participants) evaluated ten exercise modalities and optimal dosing for blood pressure reduction in adults with prehypertension or hypertension…
Incidence, 30-Day Case Fatality Rates, and Risk Factors Over Time in a Population-Based Study.
A population-based study spanning nearly 30 years reveals that stroke incidence in young adults (20–54 years) has nearly doubled, rising from 33.9 to 62.2 per 100,000 person-years, driven primarily…
An Important Window of Opportunity to Optimize Maternal Health.
This narrative review highlights the substantial long-term cardiovascular risk associated with hypertensive disorders of pregnancy and positions the postpartum period as a critical window for…
Key Updates, Historical Context, and Clinical Implications.
The 2025 AHA/ACC hypertension guideline maintains the <130/80 mmHg treatment goal but adopts a strictly risk-based approach, recommending pharmacotherapy for stage-1 hypertension once the 10-year…
consensus statement by the European Society of Hypertension Working Group on blood pressure monitoring.
The European Society of Hypertension has issued a consensus statement on wearable wristwatch cuff oscillometric blood pressure monitors. A systematic review identified only two devices (Omron…
A meta-analysis of 32 RCTs (47,332 participants) compared the blood pressure-related safety profiles of tirzepatide and semaglutide in patients with type 2 diabetes or obesity. Tirzepatide…
Intensive blood-pressure lowering reduces mortality and cardiovascular disease in clinical trials, but real-world BP measurements often differ from standardised protocols. In this retrospective…
Intensive blood-pressure lowering reduces mortality and cardiovascular disease in clinical trials, but real-world BP measurements often differ from standardised protocols. In this retrospective…
This individual-participant-data meta-analysis from the Blood Pressure Lowering Treatment Trialists' Collaboration (46 trials, 285,124 participants) examined blood-pressure lowering across all stages…