retatrutide yields up to 18.8 percent weight loss and a 10.8 mmHg lower systolic blood pressure in obesity with type 2 diabetes, with hypotension and dysesthesia as new signals
Presented at EASD 2026 in Milan and published simultaneously in The Lancet. TRIUMPH-2 randomised 1,152 adults with obesity or overweight (BMI 27 or higher, mean 38.2) and type 2 diabetes (mean HbA1c…
The Lancet Diabetes and EndocrinologyPreventionPrimary care
CagriSema lowers HbA1c by 0.16 points and weight by 4 points more than semaglutide in type 2 diabetes (REIMAGINE 2), zenagamtide follows
Amylin day at EASD 2026 in Milan. REIMAGINE 2 (Lancet Diabetes and Endocrinology) randomised 2,713 adults with type 2 diabetes on metformin with or without an SGLT2 inhibitor (mean HbA1c 8.2 percent…
retatrutide monotherapy lowers HbA1c by up to 1.1 percentage points more than placebo and body weight by up to 15 percent
Phase 3, double-blind trial in 537 adults with type 2 diabetes inadequately controlled on diet and exercise (mean HbA1c 7.9 percent, BMI 35.8, diabetes duration 2.5 years), randomised to once-weekly…
A large prospective cohort study of nearly 500,000 UK Biobank participants, combined with bidirectional Mendelian randomization, evaluated 323 modifiable risk factors for ischemic stroke. Eighteen…
A pooled analysis of five pivotal randomized trials (COMBINE-AF; n=73,737) demonstrates that extracranial bleeding occurs in 26% of patients with atrial fibrillation on oral anticoagulants over a…
1,300 ESC congress delegates measured, with excess weight in 47 percent, untreated hypertension and silent atherosclerosis in one in five
Cross-sectional health check of more than 1,300 healthcare professionals at ESC Congress 2025 with age- and sex-matched general-population controls. Excess weight 46.8 percent, hypertension 23.2…
New England Journal of MedicinePreventionPrimary care
imaging finds silent atherosclerosis in 57 percent of 16,808 adults without heart disease, and SCORE2 misses most of them
Prospective cross-sectional study in Denmark and Spain: 16,808 adults aged 18 to 70 without known cardiovascular disease, balanced by decade and sex, imaged with 3D vascular ultrasound of carotid and…
multidisciplinary, also home-based and digital, and for far more patients than the post-infarction group
Published today in the European Heart Journal ahead of its Monday presentation: the first dedicated ESC guideline on cardiac rehabilitation, chaired by Maria Bäck (Gothenburg), Matthias Wilhelm…
Aligning the timing of exercise with chronotype ('morning' or 'evening' type) may yield greater cardiometabolic benefit. In this 12-week randomised trial (Lahore, Pakistan; 150 sedentary adults aged…
The New England journal of medicinePreventionThrombosis
Cerebral amyloid angiopathy (CAA) — deposition of beta-amyloid in the brain's small vessels — is a major cause of haemorrhagic stroke and contributes to cognitive decline and to complications of…
Journal of the American Heart AssociationLifestylePrevention
Prospective cohort study in UK Biobank of 10,414 cancer survivors free of prior CVD who had completed ≥2 dietary recalls (mean age 59.5 years, 37% men). Over a median follow-up of 13.1 years, 1,331…
Journal of the American Heart AssociationDiabetesPrevention
Target trial emulation on US claims data (commercial + Medicare) of adults with type 2 diabetes and moderate cardiovascular risk who started canagliflozin (n=42,877), dapagliflozin (n=17,871), or…