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The Lancet Diabetes and EndocrinologyPreventionPrimary care

Amylin in Milan

CagriSema lowers HbA1c by 0.16 points and weight by 4 points more than semaglutide in type 2 diabetes (REIMAGINE 2), zenagamtide follows

Amylin day at EASD 2026 in Milan. REIMAGINE 2 (Lancet Diabetes and Endocrinology) randomised 2,713 adults with type 2 diabetes on metformin with or without an SGLT2 inhibitor (mean HbA1c 8.2 percent…

European journal of internal medicineKidney diseasePrimary care

CKM

Epidemiology, current clinical implications and future burden.

The cardiovascular-kidney-metabolic (CKM) syndrome framework captures the continuum linking obesity, metabolic dysfunction, chronic kidney disease, and cardiovascular disease. Population data show…

Current problems in cardiologyAtrial fibrillationPrimary care

Device-detected atrial fibrillation after ARTESiA and NOAH-AFNET 6

from episode burden to net clinical benefit.

This narrative review synthesizes evidence from the ARTESiA and NOAH-AFNET 6 trials regarding anticoagulation for device-detected atrial high-rate episodes and subclinical atrial fibrillation. While…

European heart journalKidney diseasePrimary care

Adverse pregnancy outcomes and long-term cardiovascular risk

lifelong connections.

A narrative review in the European Heart Journal highlights that adverse pregnancy outcomes, including hypertensive disorders, gestational diabetes, and preterm birth, serve as early markers of…

AtherosclerosisPreventionPrimary care

Mapping the modifiable exposome for ischemic stroke

association, causality, and preventive potential.

A large prospective cohort study of nearly 500,000 UK Biobank participants, combined with bidirectional Mendelian randomization, evaluated 323 modifiable risk factors for ischemic stroke. Eighteen…

JAMAPrimary care

ACASA-TAVI

a DOAC instead of aspirin after TAVI halves CT leaflet thrombosis and is as safe, with life-threatening bleeds only in the aspirin group

Investigator-initiated head-to-head trial in three Norwegian hospitals: 360 patients aged 65 to 80 after TAVI randomised to DOAC monotherapy (apixaban, edoxaban or rivaroxaban) or aspirin…

European Heart JournalPreventionPrimary care

The clinician as patient

1,300 ESC congress delegates measured, with excess weight in 47 percent, untreated hypertension and silent atherosclerosis in one in five

Cross-sectional health check of more than 1,300 healthcare professionals at ESC Congress 2025 with age- and sex-matched general-population controls. Excess weight 46.8 percent, hypertension 23.2…

New England Journal of MedicineHeart failurePrimary care

TRIC-I-HF

transcatheter tricuspid repair on top of medical therapy lowers death or heart failure hospitalisation at three years by 60 percent in severe tricuspid regurgitation

The hard-endpoint trial the tricuspid field lacked: 360 patients (mean 80 years, 56 percent women) with heart failure and severe tricuspid regurgitation in 29 German centres, randomised 2:1 to…

CirculationHeart failurePrimary care

TIME-HF

nurse-coordinated, digitally supported heart failure care lowers mortality by 22 percent and nearly doubles guideline therapy in India

Cluster-randomised trial in 22 Indian centres (57 percent rural): 1,507 adults with HFrEF, nurse-coordinated collaborative care with mobile health, structured counselling and real-time communication…

Cardiology and therapyCholesterolPrimary care

Beyond LDL-C

Modern Lipid Management for ASCVD Prevention in Primary Care.

This narrative review outlines the evolving landscape of lipid management for atherosclerotic cardiovascular disease (ASCVD) prevention in primary care and cardiology. Beyond traditional risk scores…

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