CagriSema lowers HbA1c by 0.16 points and weight by 4 points more than semaglutide in type 2 diabetes (REIMAGINE 2), zenagamtide follows
Amylin day at EASD 2026 in Milan. REIMAGINE 2 (Lancet Diabetes and Endocrinology) randomised 2,713 adults with type 2 diabetes on metformin with or without an SGLT2 inhibitor (mean HbA1c 8.2 percent…
European journal of internal medicineKidney diseasePrimary care
Epidemiology, current clinical implications and future burden.
The cardiovascular-kidney-metabolic (CKM) syndrome framework captures the continuum linking obesity, metabolic dysfunction, chronic kidney disease, and cardiovascular disease. Population data show…
Annals of internal medicineCholesterolPrimary care
The 2025 VA/DoD clinical practice guideline on lipid management introduces updated cardiovascular risk assessment tools, including the PREVENT calculator, one-time lipoprotein(a) testing, and…
Current problems in cardiologyAtrial fibrillationPrimary care
This narrative review synthesizes evidence from the ARTESiA and NOAH-AFNET 6 trials regarding anticoagulation for device-detected atrial high-rate episodes and subclinical atrial fibrillation. While…
A narrative review in the European Heart Journal highlights that adverse pregnancy outcomes, including hypertensive disorders, gestational diabetes, and preterm birth, serve as early markers of…
A large prospective cohort study of nearly 500,000 UK Biobank participants, combined with bidirectional Mendelian randomization, evaluated 323 modifiable risk factors for ischemic stroke. Eighteen…
Researchers developed and externally validated FIND-AF 2.0, a machine learning model using electronic health records to identify patients at high risk of developing atrial fibrillation (AF). In a…
a DOAC instead of aspirin after TAVI halves CT leaflet thrombosis and is as safe, with life-threatening bleeds only in the aspirin group
Investigator-initiated head-to-head trial in three Norwegian hospitals: 360 patients aged 65 to 80 after TAVI randomised to DOAC monotherapy (apixaban, edoxaban or rivaroxaban) or aspirin…
1,300 ESC congress delegates measured, with excess weight in 47 percent, untreated hypertension and silent atherosclerosis in one in five
Cross-sectional health check of more than 1,300 healthcare professionals at ESC Congress 2025 with age- and sex-matched general-population controls. Excess weight 46.8 percent, hypertension 23.2…
New England Journal of MedicineHeart failurePrimary care
transcatheter tricuspid repair on top of medical therapy lowers death or heart failure hospitalisation at three years by 60 percent in severe tricuspid regurgitation
The hard-endpoint trial the tricuspid field lacked: 360 patients (mean 80 years, 56 percent women) with heart failure and severe tricuspid regurgitation in 29 German centres, randomised 2:1 to…
nurse-coordinated, digitally supported heart failure care lowers mortality by 22 percent and nearly doubles guideline therapy in India
Cluster-randomised trial in 22 Indian centres (57 percent rural): 1,507 adults with HFrEF, nurse-coordinated collaborative care with mobile health, structured counselling and real-time communication…
Modern Lipid Management for ASCVD Prevention in Primary Care.
This narrative review outlines the evolving landscape of lipid management for atherosclerotic cardiovascular disease (ASCVD) prevention in primary care and cardiology. Beyond traditional risk scores…