In a multicentre cohort of 1,014 patients with persistent left ventricular dysfunction following myocardial infarction and an implanted cardioverter-defibrillator (ICD), ventricular arrhythmias (VA)…
Circulation: Population Health and OutcomesCholesterolLifestyle
pelacarsen lowers lipoprotein(a) by 86 percent in 423 Black and Hispanic Americans with cardiovascular disease, the same reduction that prevented no events in Lp(a)HORIZON
Presented in FS.12 at AHA 2026 (Monday 9 November) and published simultaneously in Circulation: Population Health and Outcomes. Lp(a)FRONTIERS EXPANSION, a US phase 3b randomised, double-blind…
New England Journal of MedicineCholesterolLifestyle
pelacarsen lowers lipoprotein(a) by 78 percent but prevents no events, hazard ratio 1.02 in 8,322 patients over 4.7 years
Presented in LBS.01 at AHA 2026 (Saturday 7 November) and published simultaneously in NEJM, with the extended analyses in NEJM Evidence. Lp(a)HORIZON randomised 8,350 patients (8,322 analysed; mean…
A systematic review and Bayesian network meta-analysis.
A Bayesian network meta-analysis of 284 RCTs (18,750 participants) evaluated ten exercise modalities and optimal dosing for blood pressure reduction in adults with prehypertension or hypertension…
An individual participant data meta-analysis of six US prospective cohorts (n = 42,257) found that common vascular risk factors—including hypertension, diabetes, chronic kidney disease, smoking, and…
Implications for Clinical Assessment of Pulmonary Vascular Disease.
In a retrospective cohort study of 1,069 patients with HFpEF undergoing invasive exercise hemodynamics, prominent V waves (PAWP V wave ≥10 mmHg above mean PAWP) were associated with markedly higher…
An Important Window of Opportunity to Optimize Maternal Health.
This narrative review highlights the substantial long-term cardiovascular risk associated with hypertensive disorders of pregnancy and positions the postpartum period as a critical window for…
Contemporary Prevention, Recognition, and Management.
This narrative review outlines contemporary strategies for preventing, recognizing, and managing major complications following transcatheter aortic valve replacement (TAVR). It emphasizes the…
This European Heart Journal review addresses the frequent loss to follow-up and care gaps when transitioning patients with inherited arrhythmia syndromes (LQTS, CPVT, Brugada) from paediatric to…
consensus statement by the European Society of Hypertension Working Group on blood pressure monitoring.
The European Society of Hypertension has issued a consensus statement on wearable wristwatch cuff oscillometric blood pressure monitors. A systematic review identified only two devices (Omron…
insights from the TEXTMEDS randomised clinical trial
Good risk-factor control and medication adherence after an acute coronary syndrome (ACS) help determine long-term prognosis, and sex plays a role. In this secondary analysis of the randomised…
An Integrated Review of a Bidirectional Relationship.
This integrated review examines the bidirectional relationship between frailty and heart failure in older adults, highlighting how frailty independently predicts incident HF while HF accelerates…