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Diabetes

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International urology and nephrologyDiabetesKidney disease

Efficacy and safety of finerenone in non-diabetic chronic kidney disease

a systematic review and meta-analysis.

A systematic review and meta-analysis demonstrates that finerenone significantly slows eGFR decline in patients with non-diabetic chronic kidney disease (difference in slope +0.70 mL/min/1.73m²/year…

CirculationDiabetes

Ez-PAVE, second randomisation

upfront statin plus ezetimibe or statin alone first gives the same outcomes in vascular disease (8.5 versus 7.9 percent), as long as you titrate to the LDL target

Presented in LBS.03 at AHA 2026 (Saturday 7 November, Byeong-Keuk Kim, Severance Hospital, Yonsei University, Seoul) and published simultaneously in Circulation. In the 2 by 2 factorial Ez-PAVE trial…

European journal of preventive cardiologyCholesterolDiabetes

Effect of Obicetrapib on Glycaemia and New-Onset Diabetes

Pooled Analysis of BROADWAY/BROOKLYN and an Updated Meta-analysis of CETP Inhibitor Trials.

A pooled analysis of phase 3 trials (BROADWAY/BROOKLYN) and an updated meta-analysis evaluated the impact of the CETP inhibitor obicetrapib on glycaemia and new-onset diabetes in 1,700 participants…

Journal of cardiovascular pharmacologyDiabetesKidney disease

Finerenone

A Non-Steroidal Mineralocorticoid Receptor Antagonist and Its Emerging Role in Cardiovascular-Kidney-Metabolic Syndrome.

This narrative review synthesizes evidence for finerenone in cardiovascular-kidney-metabolic (CKM) syndrome, drawing on phase 3 trials including FIDELIO-DKD, FIGARO-DKD, FINEARTS-HF, and the pooled…

Cardiology clinicsDiabetesHeart failure

Current Medical Therapy in Epicardial and Microvascular Disease

Evidence and Gaps.

The management of chronic coronary syndromes is shifting from an obstructive to a phenotype-guided approach, encompassing INOCA, vasospastic angina, and coronary microvascular dysfunction. While…

NeurologyDiabetesHypertension

Stroke in the Young

Incidence, 30-Day Case Fatality Rates, and Risk Factors Over Time in a Population-Based Study.

A population-based study spanning nearly 30 years reveals that stroke incidence in young adults (20–54 years) has nearly doubled, rising from 33.9 to 62.2 per 100,000 person-years, driven primarily…

Diabetes & metabolismDiabetesKidney disease

Perioperative management of SGLT2 inhibitors

balancing euglycaemic ketoacidosis risk and cardiorenal benefits.

This review addresses the perioperative management of SGLT2 inhibitors in patients with heart failure, chronic kidney disease, or type 2 diabetes. While guidelines typically recommend withholding the…

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