A systematic review and meta-analysis demonstrates that finerenone significantly slows eGFR decline in patients with non-diabetic chronic kidney disease (difference in slope +0.70 mL/min/1.73m²/year…
Journal of the American Heart AssociationCholesterolDiabetes
In a prospective cohort study of 18,741 patients with type 2 diabetes on lipid-lowering therapy, elevated remnant cholesterol and hsCRP levels were each independently associated with a higher risk of…
upfront statin plus ezetimibe or statin alone first gives the same outcomes in vascular disease (8.5 versus 7.9 percent), as long as you titrate to the LDL target
Presented in LBS.03 at AHA 2026 (Saturday 7 November, Byeong-Keuk Kim, Severance Hospital, Yonsei University, Seoul) and published simultaneously in Circulation. In the 2 by 2 factorial Ez-PAVE trial…
A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
A meta-analysis of 85 randomized trials (70,543 participants) demonstrates that SGLT2 inhibitors produce a small but statistically significant increase in hemoglobin (+0.60 g/dl) and hematocrit…
European journal of preventive cardiologyCholesterolDiabetes
Pooled Analysis of BROADWAY/BROOKLYN and an Updated Meta-analysis of CETP Inhibitor Trials.
A pooled analysis of phase 3 trials (BROADWAY/BROOKLYN) and an updated meta-analysis evaluated the impact of the CETP inhibitor obicetrapib on glycaemia and new-onset diabetes in 1,700 participants…
Journal of cardiovascular pharmacologyDiabetesKidney disease
A Non-Steroidal Mineralocorticoid Receptor Antagonist and Its Emerging Role in Cardiovascular-Kidney-Metabolic Syndrome.
This narrative review synthesizes evidence for finerenone in cardiovascular-kidney-metabolic (CKM) syndrome, drawing on phase 3 trials including FIDELIO-DKD, FIGARO-DKD, FINEARTS-HF, and the pooled…
Signal transduction and targeted therapyDiabetesKidney disease
In a multicenter ambispective cohort of 3,305 patients with type 2 diabetes and chronic kidney disease, polyethylene glycol-loxenatide demonstrated significant renoprotective effects compared to…
The management of chronic coronary syndromes is shifting from an obstructive to a phenotype-guided approach, encompassing INOCA, vasospastic angina, and coronary microvascular dysfunction. While…
Incidence, 30-Day Case Fatality Rates, and Risk Factors Over Time in a Population-Based Study.
A population-based study spanning nearly 30 years reveals that stroke incidence in young adults (20–54 years) has nearly doubled, rising from 33.9 to 62.2 per 100,000 person-years, driven primarily…
balancing euglycaemic ketoacidosis risk and cardiorenal benefits.
This review addresses the perioperative management of SGLT2 inhibitors in patients with heart failure, chronic kidney disease, or type 2 diabetes. While guidelines typically recommend withholding the…
Journal of the American Society of NephrologyDiabetesHeart failure
A real-world cohort study of nearly 46,000 patients evaluated whether glucosuria on routine urinalysis serves as a practical proxy for adherence to SGLT2 inhibitors. After inverse probability…
A systematic review of pooled analyses from the FIDELITY programme demonstrates that finerenone significantly reduces composite renal and cardiovascular outcomes in patients with diabetic kidney…