Epidemiology, current clinical implications and future burden.
The cardiovascular-kidney-metabolic (CKM) syndrome framework captures the continuum linking obesity, metabolic dysfunction, chronic kidney disease, and cardiovascular disease. Population data show…
An international target trial emulation involving 64,036 patients on dialysis demonstrates that deceased donor kidney transplantation using standard criteria donors (SCD) significantly improves…
balancing euglycaemic ketoacidosis risk and cardiorenal benefits.
This review addresses the perioperative management of SGLT2 inhibitors in patients with heart failure, chronic kidney disease, or type 2 diabetes. While guidelines typically recommend withholding the…
A Scientific Statement From the American Heart Association.
The American Heart Association has released a scientific statement highlighting sex-specific differences in chronic kidney disease (CKD), emphasizing biological factors, underrepresentation in…
A systematic review of pooled analyses from the FIDELITY programme demonstrates that finerenone significantly reduces composite renal and cardiovascular outcomes in patients with diabetic kidney…
A post-hoc analysis of the CREDENCE trial found that canagliflozin maintains consistent efficacy and safety across varying levels of polypharmacy in patients with type 2 diabetes and chronic kidney…
Chronic kidney disease is driven by a pro-inflammatory state that accelerates both renal decline and major cardiovascular events. This review outlines key inflammatory pathways and highlights…
A narrative review in the European Heart Journal highlights that adverse pregnancy outcomes, including hypertensive disorders, gestational diabetes, and preterm birth, serve as early markers of…
The Lancet regional health. EuropeDiabetesKidney disease
A multicentre cross-sectional study of 15,879 adults in the UK compared five creatinine-based eGFR equations against measured GFR. The Lund-Malmö Revised (LMR) and EKFC equations demonstrated the…
In a large retrospective target trial emulation using electronic health records, initiation of GLP-1 receptor agonists versus SGLT2 inhibitors was associated with significantly lower 4-year all-cause…
eGFR and albuminuria for every cardiac patient, an SGLT2 inhibitor regardless of ejection fraction, and a chair from Groningen
Published today in the European Heart Journal ahead of its Saturday presentation: the first ESC guideline that treats cardiovascular disease and chronic kidney disease as one condition, endorsed by…
Chronic kidney disease in type 2 diabetes affects 30–40% of patients and substantially increases cardiovascular risk and mortality. Recent evidence supports the simultaneous use of SGLT2 inhibitors…