Investigator-initiated RCT in 21 centres in Italy and Pakistan: 1,823 STEMI patients with multivessel disease randomised to complete revascularisation guided by angiography-derived FFR (non-culprit lesions treated only if FFR 0.80 or lower) versus angiography-guided PCI of every lesion of 50 percent or more. Death, MI, stroke or ischaemia-driven revascularisation at median 17.9 months 8.9 versus 13.7 percent (HR 0.62, 95% CI 0.47 to 0.83, p under 0.001); contrast nephropathy or major bleeding 4.6 versus 7.1 percent. Hot Line 4, NEJM.
