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Aug. 28, 2026

CMR GUIDE

an ICD for scar on CMR with LVEF 36 to 50 percent misses its primary endpoint but reduces sudden cardiac death, with benefit confined to patients under 70

Selvanayagam JB, et al.; CMR GUIDE investigators - JAMA

353 patients with LVEF 36 to 50 percent on optimal therapy and myocardial scar on cardiovascular magnetic resonance (ischaemic or non-ischaemic, 18 centres in Australia, Germany and the UK) were randomised to an ICD or an implantable loop recorder. The primary composite of sudden cardiac death or haemodynamically significant ventricular arrhythmia was 7.8 versus 9.2 percent (HR 0.76, 95% CI 0.37 to 1.58). Sudden cardiac death alone: 1.7 versus 5.8 percent (HR 0.26, 95% CI 0.07 to 0.95). Under 70 the primary endpoint fell by 72 percent; at 70 and over there was no benefit. Hot Line 1, JAMA.